Deregulation of Developmental Genes in Pancreatic Malignancies
نویسندگان
چکیده
منابع مشابه
Deregulation of Developmental Genes in Pancreatic Malignancies
The concept that neoplastic diseases are characterized by a deregulation of the genes that control, during embryogenesis, the correct development it has now been fully accepted by the scientific community. In fact, the common mechanisms between the two processes are very numerous, and for this reason at the end of eighties, the role of developmental genes in neoplastic transformation and progre...
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Posttranslational modifications of histone proteins represent a fundamental means to define distinctive epigenetic states and regulate gene expression during development and differentiation. Aberrations in various chromatin-modulation pathways are commonly used by tumors to initiate and maintain oncogenesis, including lymphomagenesis. Recently, increasing evidence has demonstrated that polycomb...
متن کاملTitle Polycomb Genes , miRNA , and Their Deregulation in B - cell Malignancies Gang
Correspondence: Dr. Jianguo Tao, Departments of Hematopathology and Laboratory Medicine, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA; email: [email protected] tel: 813-745-3885 fax: 813-745-1708 Co-correspondence: Dr. G. Greg Wang, Lineberger Comprehensive Cancer Center,University of North Carolina at Chapel Hill, 450 West Dr, CB 7295,Chapel Hill, NC 27599; e-mail: ...
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Endogenous cytokines are aberrantly produced in many cancers and serve as autocrine growth factors or indicators of immune response to the tumors. Hence, cytokine deregulation is likely to participate in the development or evolution of the malignant process. Over the last few years, we have performed a series of studies, with the objective of measuring cytokine levels in tumors and correlating ...
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ژورنال
عنوان ژورنال: Pancreatic Disorders & Therapy
سال: 2012
ISSN: 2165-7092
DOI: 10.4172/2165-7092.1000e119